The intravenous administration of neutral red in the normal anesthetized dog produces
hyperglycemia, an increase in the secretions of glucagon and insulin measured in the
pancreatico-duodenal vein, a sharp drop in the arterial blood pressure and an increase
in the secretion of catecholamines by the adrenal medulla. In adrenalectomized dogs
there is no significant increase in the glycemia, the average secretions of insulin
and of glucagon rise but in a less striking manner than in the normal dog. The hyperglycemia
produced by neutral red, while due in part to the secretion of glucagon, is also the
result of other factors, particularly the catecholamine secretion by the adrenal glands.
It is important to take note of the strong hypotension produced by the intravenous
administration of neutral red.
Neutral Red - Glycemia - Glucagon Secretion - Insulin Secretion - Blood Pressure -
Catecholamines Release - Adrenalectomized Dogs
